Job Description
NexGen Biopharma is seeking a visionary Principal Scientist to join our Oncology Drug Discovery team in the heart of Cambridge's biotech corridor. We are at the forefront of precision medicine, developing next-generation therapeutics that redefine patient outcomes. This is a high-impact role designed for a researcher who thrives on innovation, scientific rigor, and the pursuit of life-saving breakthroughs.
As a key leader in our R&D department, you will bridge the gap between early-stage target identification and clinical development. You will leverage our proprietary AI-driven discovery platform and state-of-the-art laboratory facilities to accelerate the transition of novel compounds from bench to bedside. We offer a culture of intellectual curiosity, premium benefits, and a mission-driven environment where scientific excellence is the standard.
Responsibilities
- Lead the strategy and execution of small molecule drug discovery programs from hit identification through IND filing.
- Supervise and mentor a high-performing team of research scientists, fostering a culture of innovation and technical growth.
- Collaborate with bioinformatics and clinical pharmacology teams to validate novel therapeutic targets and biomarkers.
- Directly manage external research collaborations with global academic institutions and Tier-1 CRO partners.
- Present scientific findings and project milestones to executive leadership and the Board of Directors.
- Maintain rigorous documentation and ensure compliance with all global regulatory and safety standards.
Qualifications
- Ph.D. in Molecular Biology, Oncology, Pharmacology, or a related life sciences discipline.
- Minimum of 6 years of post-doctoral experience, with at least 4 years in a leadership role within a biotech or pharmaceutical setting.
- Proven track record of scientific excellence demonstrated by high-impact publications or successful patent filings.
- Deep expertise in oncology signaling pathways and advanced target validation techniques (e.g., CRISPR, RNAi).
- Exceptional leadership and communication skills, with the ability to influence cross-functional teams.
- Previous experience navigating the IND submission process and interacting with regulatory bodies is highly preferred.